WORKLIST ENTRIES (1):

GLHYDRLASE39 View alignment     Glycosyl hydrolase family 39 signature
 Type of fingerprint: COMPOUND with 7  elements
Links:
   PRINTS; PR00131 GLHYDRLASE1; PR00132 GLHYDRLASE2; PR00133 GLHYDRLASE3
   PRINTS; PR00732 GLHYDRLASE4; PR00733 GLHYDRLASE6; PR00734 GLHYDRLASE7
   PRINTS; PR00735 GLHYDRLASE8; PR00134 GLHYDRLASE10; PR00911 GLHYDRLASE11
   PRINTS; PR00736 GLHYDRLASE15; PR00737 GLHYDRLASE16; PR00738 GLHYDRLASE20
   PRINTS; PR00739 GLHYDRLASE26; PR00740 GLHYDRLASE27; PR00741 GLHYDRLASE29
   PRINTS; PR00843 GLHYDRLASE30; PR00742 GLHYDRLASE35; PR00743 GLHYDRLASE36
   PRINTS; PR00744 GLHYDRLASE37; PR00746 GLHYDRLASE41; PR00747 GLHYDRLASE47
   PRINTS; PR00844 GLHYDRLASE48; PR00845 GLHYDRLASE52; PR00846 GLHYDRLASE56
   PRINTS; PR00849 GLHYDRLASE58; PR00850 GLHYDRLASE59; PR00748 MELIBIASE
   PRINTS; PR00137 LYSOZYME; PR00684 T4LYSOZYME; PR00749 LYSOZYMEG
   PRINTS; PR00110 ALPHAAMYLASE; PR00750 BETAAMYLASE
   INTERPRO; IPR000514
   PROSITE; PS01027 GLYCOSYL_HYDROL_F39
   PFAM; PF01229 Glycosyl_hydr19

 Creation date 11-JUN-1997; UPDATE 07-JUN-1999

   1. HENRISSAT, B. AND BAIROCH, A.
   New families in the classification of glycosyl hydrolases based on amino
   acid sequence similarities.
   BIOCHEM.J. 293 781-788 (1993).

   2. HENRISSAT, B.
   A classification of glycosyl hydrolases based on amino acid sequence
   similarities.
   BIOCHEM.J. 280 309-316 (1991).

   3. DAVIES, G. AND HENRISSAT, B.
   Structures and mechanisms of glycosyl hydrolases.
   STRUCTURE 3 853-859 (1995).

   4. HENRISSAT, B. AND BAIROCH, A.
   Updating the sequence-based classification of glycosyl hydrolases.
   BIOCHEM.J. 316 695-696 (1996).

   5. STOLTZFUS, L.J., SOSA-PINEDA, B., MOSKOWITZ, S.M., MENON, K.P.,
   DLOTT, B., HOOPER, L., TEPLOW, D.B., SHULL, R.M. AND NEUFELD, E.F.
   Cloning and characterization of cDNA encoding canine alpha-L-iduronidase.
   mRNA deficiency in mucopolysaccharidosis I dog.
   J.BIOL.CHEM. 267(10) 6570-6575 (1992). 

   O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that
   hydrolyse the glycosidic bond between two or more carbohydrates, or between
   a carbohydrate and a non-carbohydrate moiety. A classification system for
   glycosyl hydrolases, based on sequence similarity, has led to the definition
   of up to 60 different families [1-4] (http://expasy.hcuge.ch/cgi-bin/lists?
   glycosid.txt). Family 39 encompasses mammalian alpha-L-iduronidases and some
   bacterial beta-xylosidases.
   
   Alpha-L-iduronidase is a lysosomal enzyme, deficiency of which causes muco-
   polysaccharidosis I (MPS I) [5]. The enzyme hydrolyses alpha-L-iduronosidic
   linkages in desulphated dermatan.
   
   GLHYDRLASE39 is a 7-element fingerprint that provides a signature for
   family 39 glycosyl hydrolases. The fingerprint was derived from an initial
   alignment of 5 sequences: the motifs were drawn from conserved regions 
   spanning the central portion of the alignment - motif 3 includes the
   region encoded by PROSITE pattern GLYCOSYL_HYDROL_F39 (PS01027), which
   contains a Glu residue that may act as the proton donor in the catalytic
   mechanism. A single iteration on OWL29.3 was required to reach convergence,
   no further sequences being identified beyond the starting set.
  
   An update on SPTR37_9f identified a true set of 6 sequences, and 1
   partial match.

  SUMMARY INFORMATION
      6 codes involving  7 elements
      1 codes involving  6 elements
      0 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    7|   6    6    6    6    6    6    6  
    6|   1    1    1    1    1    1    0  
    5|   0    0    0    0    0    0    0  
    4|   0    0    0    0    0    0    0  
    3|   0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0  
   --+------------------------------------
     |   1    2    3    4    5    6    7  

True positives..
 IDUA_HUMAN     IDUA_CANFA     IDUA_MOUSE     XYNB_THESA     
 O30360         XYNB_CALSA     
Subfamily:  Codes involving 6 elements
 Subfamily True positives..
 O30428         


  PROTEIN TITLES
   IDUA_HUMAN       ALPHA-L-IDURONIDASE PRECURSOR (EC 3.2.1.76) - HOMO SAPIENS (
   IDUA_CANFA       ALPHA-L-IDURONIDASE PRECURSOR (EC 3.2.1.76) - CANIS FAMILIAR
   IDUA_MOUSE       ALPHA-L-IDURONIDASE PRECURSOR (EC 3.2.1.76) - MUS MUSCULUS (
   XYNB_THESA       BETA-XYLOSIDASE (EC 3.2.1.37) (1,4-BETA-D-XYLAN XYLOHYDROLAS
   O30360           BETA-XYLOSIDASE - THERMOANAEROBACTERIUM SP. 'JW/SL YS485'.
   XYNB_CALSA       BETA-XYLOSIDASE (EC 3.2.1.37) (1,4-BETA-D-XYLAN XYLOHYDROLAS
 
   O30428           XYLANASE - CALDOCELLUM SACCHAROLYTICUM (CALDICELLULOSIRUPTOR

SCAN HISTORY OWL29_3 1 25 NSINGLE SPTR37_9f 2 7 NSINGLE INITIAL MOTIF SETS GLHYDRLASE391 Length of motif = 17 Motif number = 1 Glycosyl hydrolase family 39 motif I - 1 PCODE ST INT LDGYLDLLRENQLLPGF IDUA_CANFA 113 113 LDGYLDLLRENQLLPGF IDUA_HUMAN 114 114 LDAFLDLLMENQLLPGF IDUA_MOUSE 104 104 FDSFLEIGIRPFVEIGF XYNB_THESA 86 86 IDFLLEIGMKPFIELSF XYNB_CALSA 89 89 GLHYDRLASE392 Length of motif = 18 Motif number = 2 Glycosyl hydrolase family 39 motif II - 1 PCODE ST INT LVSLLARRYIGRYGLSYV IDUA_CANFA 154 24 LVSSLARRYIGRYGLAHV IDUA_HUMAN 155 24 LVSLLARRYIGRYGLTHV IDUA_MOUSE 145 24 LVKAVLHHFISRYGIEEV XYNB_THESA 133 30 LIEELARHLISRYGKNEV XYNB_CALSA 136 30 GLHYDRLASE393 Length of motif = 17 Motif number = 3 Glycosyl hydrolase family 39 motif III - 1 PCODE ST INT VSKWNFETWNEPDHHDF IDUA_CANFA 171 -1 VSKWNFETWNEPDHHDF IDUA_HUMAN 172 -1 VSKWNFETWNEPDHHDF IDUA_MOUSE 162 -1 VLKWPFEIWNEPNLKEF XYNB_THESA 150 -1 VREWFFEVWNEPNLKDF XYNB_CALSA 153 -1 GLHYDRLASE394 Length of motif = 15 Motif number = 4 Glycosyl hydrolase family 39 motif IV - 1 PCODE ST INT FTGELGVRLDYISLH IDUA_CANFA 247 59 FTGEAGVRLDYISLH IDUA_HUMAN 248 59 FTGEVGVRLDYISLH IDUA_MOUSE 238 59 FCYEENVPVDFVSRH XYNB_THESA 214 47 FCTKNGVPIDFISTH XYNB_CALSA 215 45 GLHYDRLASE395 Length of motif = 18 Motif number = 5 Glycosyl hydrolase family 39 motif V - 1 PCODE ST INT PWRADVTYAAMVVKVVAQ IDUA_CANFA 310 48 PWRADVTYAAMVVKVIAQ IDUA_HUMAN 311 48 PWRADVTYAALVVKVIAQ IDUA_MOUSE 301 48 PVHDTPFNAAYIARILSE XYNB_THESA 287 58 PYHDIPYDAAFIVKTIID XYNB_CALSA 285 55 GLHYDRLASE396 Length of motif = 12 Motif number = 6 Glycosyl hydrolase family 39 motif VI - 1 PCODE ST INT LDNPRCSPHGEW IDUA_CANFA 475 147 LDNGLCSPDGEW IDUA_HUMAN 476 147 LDNQLSSPYSAW IDUA_MOUSE 466 147 IDEEHGNPWGTW XYNB_THESA 415 110 IDEYNANPKRVW XYNB_CALSA 420 117 GLHYDRLASE397 Length of motif = 15 Motif number = 7 Glycosyl hydrolase family 39 motif VII - 1 PCODE ST INT WQRLGRPVFPTAEEF IDUA_CANFA 486 -1 WRRLGRPVFPTAEQF IDUA_HUMAN 487 -1 WQHMGQPVFPSAEQF IDUA_MOUSE 477 -1 WIHMGRPRYPSKEQV XYNB_THESA 426 -1 WLEMGSPAYLNREQI XYNB_CALSA 431 -1 FINAL MOTIF SETS GLHYDRLASE391 Length of motif = 17 Motif number = 1 Glycosyl hydrolase family 39 motif I - 2 PCODE ST INT LDGYLDLLRENQLLPGF IDUA_HUMAN 114 114 LDGYLDLLRENQLLPGF IDUA_CANFA 113 113 LDAFLDLLMENQLLPGF IDUA_MOUSE 104 104 FDSFLEIGIRPFVEIGF XYNB_THESA 86 86 FDSFLEIGIRPFVEIGF O30360 86 86 IDFLLEIGMKPFIELSF XYNB_CALSA 89 89 GLHYDRLASE392 Length of motif = 18 Motif number = 2 Glycosyl hydrolase family 39 motif II - 2 PCODE ST INT LVSSLARRYIGRYGLAHV IDUA_HUMAN 155 24 LVSLLARRYIGRYGLSYV IDUA_CANFA 154 24 LVSLLARRYIGRYGLTHV IDUA_MOUSE 145 24 LVKAVLHHFISRYGIEEV XYNB_THESA 133 30 LIKAVVSHFISRYGIDEV O30360 133 30 LIEELARHLISRYGKNEV XYNB_CALSA 136 30 GLHYDRLASE393 Length of motif = 17 Motif number = 3 Glycosyl hydrolase family 39 motif III - 2 PCODE ST INT VSKWNFETWNEPDHHDF IDUA_HUMAN 172 -1 VSKWNFETWNEPDHHDF IDUA_CANFA 171 -1 VSKWNFETWNEPDHHDF IDUA_MOUSE 162 -1 VLKWPFEIWNEPNLKEF XYNB_THESA 150 -1 VAKWPFEIWNEPNLKEF O30360 150 -1 VREWFFEVWNEPNLKDF XYNB_CALSA 153 -1 GLHYDRLASE394 Length of motif = 15 Motif number = 4 Glycosyl hydrolase family 39 motif IV - 2 PCODE ST INT FTGEAGVRLDYISLH IDUA_HUMAN 248 59 FTGELGVRLDYISLH IDUA_CANFA 247 59 FTGEVGVRLDYISLH IDUA_MOUSE 238 59 FCYEENVPVDFVSRH XYNB_THESA 214 47 FCYEENVPVDFVSRH O30360 214 47 FCTKNGVPIDFISTH XYNB_CALSA 215 45 GLHYDRLASE395 Length of motif = 18 Motif number = 5 Glycosyl hydrolase family 39 motif V - 2 PCODE ST INT PWRADVTYAAMVVKVIAQ IDUA_HUMAN 311 48 PWRADVTYAAMVVKVVAQ IDUA_CANFA 310 48 PWRADVTYAALVVKVIAQ IDUA_MOUSE 301 48 PVHDTPFNAAYIARILSE XYNB_THESA 287 58 PVHDTPFNAAYIARILSE O30360 287 58 PYHDIPYDAAFIVKTIID XYNB_CALSA 285 55 GLHYDRLASE396 Length of motif = 12 Motif number = 6 Glycosyl hydrolase family 39 motif VI - 2 PCODE ST INT LDNGLCSPDGEW IDUA_HUMAN 476 147 LDNPRCSPHGEW IDUA_CANFA 475 147 LDNQLSSPYSAW IDUA_MOUSE 466 147 IDEEHGNPWGTW XYNB_THESA 415 110 IDEEHGNPWGTW O30360 415 110 IDEYNANPKRVW XYNB_CALSA 420 117 GLHYDRLASE397 Length of motif = 15 Motif number = 7 Glycosyl hydrolase family 39 motif VII - 2 PCODE ST INT WRRLGRPVFPTAEQF IDUA_HUMAN 487 -1 WQRLGRPVFPTAEEF IDUA_CANFA 486 -1 WQHMGQPVFPSAEQF IDUA_MOUSE 477 -1 WIHMGRPRYPSKEQV XYNB_THESA 426 -1 WIHMGRPRYPSKKEI O30360 426 -1 WLEMGSPAYLNREQI XYNB_CALSA 431 -1

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