WORKLIST ENTRIES (1):

GLHYDRLASE37 View alignment     Glycosyl hydrolase family 37 signature
 Type of fingerprint: COMPOUND with 7  elements
Links:
   PRINTS; PR00131 GLHYDRLASE1; PR00132 GLHYDRLASE2; PR00133 GLHYDRLASE3
   PRINTS; PR00732 GLHYDRLASE4; PR00733 GLHYDRLASE6; PR00734 GLHYDRLASE7
   PRINTS; PR00735 GLHYDRLASE8; PR00134 GLHYDRLASE10; PR00911 GLHYDRLASE11
   PRINTS; PR00736 GLHYDRLASE15; PR00737 GLHYDRLASE16; PR00738 GLHYDRLASE20
   PRINTS; PR00739 GLHYDRLASE26; PR00740 GLHYDRLASE27; PR00741 GLHYDRLASE29
   PRINTS; PR00843 GLHYDRLASE30; PR00742 GLHYDRLASE35; PR00743 GLHYDRLASE36
   PRINTS; PR00745 GLHYDRLASE39; PR00746 GLHYDRLASE41; PR00747 GLHYDRLASE47
   PRINTS; PR00844 GLHYDRLASE48; PR00845 GLHYDRLASE52; PR00846 GLHYDRLASE56
   PRINTS; PR00849 GLHYDRLASE58; PR00850 GLHYDRLASE59; PR00748 MELIBIASE
   PRINTS; PR00137 LYSOZYME; PR00684 T4LYSOZYME; PR00749 LYSOZYMEG
   PRINTS; PR00110 ALPHAAMYLASE; PR00750 BETAAMYLASE
   INTERPRO; IPR001661
   PROSITE; PS00927 TREHALASE_1; PS00928 TREHALASE_2
   PFAM; PF01204 Trehalase 

 Creation date 12-JUN-1997; UPDATE 07-JUN-1999

   1. HENRISSAT, B. AND BAIROCH, A.
   New families in the classification of glycosyl hydrolases based on amino
   acid sequence similarities.
   BIOCHEM.J. 293 781-788 (1993).

   2. HENRISSAT, B.
   A classification of glycosyl hydrolases based on amino acid sequence
   similarities.
   BIOCHEM.J. 280 309-316 (1991).

   3. DAVIES, G. AND HENRISSAT, B.
   Structures and mechanisms of glycosyl hydrolases.
   STRUCTURE 3 853-859 (1995).

   4. HENRISSAT, B. AND BAIROCH, A.
   Updating the sequence-based classification of glycosyl hydrolases.
   BIOCHEM.J. 316 695-696 (1996).

   5. KOPP, M., MUELLER, H. AND HOLZER, H.
   Molecular analysis of the neutral trehalase gene from Saccharomyces
   cerevisiae.
   J.BIOL.CHEM. 268 4766-4774 (1993).

   O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that
   hydrolyse the glycosidic bond between two or more carbohydrates, or between
   a carbohydrate and a non-carbohydrate moiety. A classification system for
   glycosyl hydrolases, based on sequence similarity, has led to the definition
   of up to 60 different families [1-4] (http://expasy.hcuge.ch/cgi-bin/lists?
   glycosid.txt). 
  
   Family 37 encompasses trehalases. These enzymes are responsible for
   degradation of the disaccharide alpha,alpha-trehalose, yielding two glucose
   units [5]:
      		alpha,alpha-trehalose + H(2)O = 2 D-glucose
  
   GLHYDRLASE37 is a 7-element fingerprint that provides a signature for
   family 37 glycosyl hydrolases. The fingerprint was derived from an initial
   alignment of 8 sequences: the motifs were drawn from conserved regions 
   spanning the C-terminal half of the alignment - motif 6 includes the
   region encoded by PROSITE pattern TREHALASE_2(PS00928). Two iterations
   on OWL29.3 were required to reach convergence, at which point a true set
   comprising 14 sequences was identified. Three partial matches were also
   found, all of which are fragments.
  
   An update on SPTR37_9f identified a true set of 19 sequences, and 1
   partial match.

  SUMMARY INFORMATION
     19 codes involving  7 elements
      1 codes involving  6 elements
      0 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    7|  19   19   19   19   19   19   19  
    6|   1    0    1    1    1    1    1  
    5|   0    0    0    0    0    0    0  
    4|   0    0    0    0    0    0    0  
    3|   0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0  
   --+------------------------------------
     |   1    2    3    4    5    6    7  

True positives..
 TREB_MAGGR     TREB_EMENI     TREB_NEUCR     TREA_CANAL     
 TREA_KLULA     TREA_YEAST     TREA_SCHPO     TREA_RABIT     
 TREB_YEAST     TREA_BOMMO     TREA_HUMAN     Q27453         
 TREA_ECOLI     Q22195         O22986         TREF_ECOLI     
 TREA_TENMO     Q23176         O44736         
Subfamily:  Codes involving 6 elements
 Subfamily True positives..
 Q19472         


  PROTEIN TITLES
   TREB_MAGGR       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREB_EMENI       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREB_NEUCR       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREA_CANAL       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREA_KLULA       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREA_YEAST       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREA_SCHPO       NEUTRAL TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (ALP
   TREA_RABIT       TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (A
   TREB_YEAST       PROBABLE TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (AL
   TREA_BOMMO       TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (A
   TREA_HUMAN       TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (A
   Q27453           TREHALASE (EC 3.2.1.28) - BOMBYX MORI (SILK MOTH).
   TREA_ECOLI       PERIPLASMIC TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-T
   Q22195           SIMILAR TO TREHALASE PRECURSOR. NCBI GI: 1086612 - CAENORHAB
   O22986           TREHALASE PRECUSOR ISOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR 
   TREF_ECOLI       PROBABLE CYTOPLASMIC TREHALASE (EC 3.2.1.28) (ALPHA,ALPHA-TR
   TREA_TENMO       TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) (A
   Q23176           W05E10.4 PROTEIN - CAENORHABDITIS ELEGANS.
   O44736           F57B10.7 PROTEIN - CAENORHABDITIS ELEGANS.
 
   Q19472           F15A2.2 PROTEIN - CAENORHABDITIS ELEGANS.

SCAN HISTORY OWL29_3 2 100 NSINGLE SPTR37_9f 2 24 NSINGLE INITIAL MOTIF SETS GLHYDRLASE371 Length of motif = 19 Motif number = 1 Glycosyl hydrolase family 37 motif I - 1 PCODE ST INT YGHIPNGNRSYYLSRSQPP TREA_ECOLI 191 191 YGHIPNGGRVYYLQRSQPP TREA_RABIT 207 207 YGHIPNGNRTYYLSRSQPP TREF_ECOLI 207 207 YGKILNANRSYYLCRSQPP TREA_KLULA 344 344 YGKILNANRSYYLCRSQPP TREA_YEAST 341 341 YSKILNANRSYYLCRSQPP TREB_YEAST 370 370 YGFIPNGARVFYLNRSQPP TREA_TENMO 203 203 FGHIPNGSRWYYQERSQPP TREA_BOMMO 200 200 GLHYDRLASE372 Length of motif = 18 Motif number = 2 Glycosyl hydrolase family 37 motif II - 1 PCODE ST INT LNRYWDDRDTPRPESWVE TREA_ECOLI 266 56 LNRYHVPYGGPRPESYSK TREA_RABIT 275 49 LNRYWDDRDTPRDESWLE TREF_ECOLI 281 55 LSCYHPDGIGIPPETEPG TREA_KLULA 414 51 LSRYHPNGLGIPPETESD TREA_YEAST 411 51 LSCYHSDGIGIPPETEPD TREB_YEAST 440 51 LAQYNSNSGSPRPESYYE TREA_TENMO 271 49 LLRYYIPSAGPRPESYYE TREA_BOMMO 268 49 GLHYDRLASE373 Length of motif = 18 Motif number = 3 Glycosyl hydrolase family 37 motif III - 1 PCODE ST INT YRDLRSAAASGWDFSSRW TREA_ECOLI 300 16 WAELKAGAESGWDFSSRW TREA_RABIT 309 16 YRDLRAGAASGWDYSSRW TREF_ECOLI 314 15 FLHDRGVRESGHDTTYRF TREA_KLULA 469 37 FLHDRGVRESGHDTTYRF TREA_YEAST 466 37 FLHDRAVRESGHDTTYRF TREB_YEAST 495 37 YMDLKSAAESGWDFSSRW TREA_TENMO 306 17 YADLKSAAESGWDFSTRW TREA_BOMMO 303 17 GLHYDRLASE374 Length of motif = 18 Motif number = 4 Glycosyl hydrolase family 37 motif IV - 1 PCODE ST INT IVPVDLNSLMFKMEKILA TREA_ECOLI 332 14 LVPVDLNAFLCQAEELLS TREA_RABIT 344 17 FIPIDLNAFLFKLESAIA TREF_ECOLI 346 14 LATIDLNSLLYKYEVDIA TREA_KLULA 493 6 LATIDLNSLLYKYEIDIA TREA_YEAST 490 6 LATIDLNSLLYKYEKDIA TREB_YEAST 519 6 IIPVDLNAFLCQAFQKLS TREA_TENMO 343 19 VIPVDLNAIFAGALQITA TREA_BOMMO 340 19 GLHYDRLASE375 Length of motif = 17 Motif number = 5 Glycosyl hydrolase family 37 motif V - 1 PCODE ST INT IEKYLWNDQQGWYADYD TREA_ECOLI 375 25 LTALLWDEDKGAWFDYD TREA_RABIT 387 25 VNRYLWDDENGIYRDYD TREF_ECOLI 389 25 IDKYLWDEETGFYYDYN TREA_KLULA 545 34 ITKYMWDDESGFFFDYN TREA_YEAST 543 35 INKYMWDEDSGFFFYYN TREB_YEAST 572 35 IEMVHYNRDDGIWYDWD TREA_TENMO 386 25 IEQALWDEEDGVWHDYD TREA_BOMMO 383 25 GLHYDRLASE376 Length of motif = 17 Motif number = 6 Glycosyl hydrolase family 37 motif VI - 1 PCODE ST INT TSVKSGQQWDAPNGWAP TREA_ECOLI 439 47 SLQNTGQQWDFPNAWAP TREA_RABIT 454 50 SEYETGEQWDKPNGWAP TREF_ECOLI 452 46 SLDRPTRQWDYPFGWAP TREA_KLULA 618 56 SISRPIRQWDYPFGWAP TREA_YEAST 616 56 SIDRPIRQWDYPFGWAP TREB_YEAST 645 56 SLSHTGEQWDYPNAWPP TREA_TENMO 456 53 SLVNSGEQWDFPNAWPP TREA_BOMMO 453 53 GLHYDRLASE377 Length of motif = 14 Motif number = 7 Glycosyl hydrolase family 37 motif VII - 1 PCODE ST INT DGFGWTNGVTLKML TREA_ECOLI 516 60 EGFGWTNGVALMLL TREA_RABIT 533 62 DGFGWTNGVVRRLI TREF_ECOLI 530 61 EGFGWVNSSYLLGM TREA_KLULA 706 71 EGFGWVNASYILGL TREA_YEAST 704 71 EGFGWVNTSYLLGL TREB_YEAST 733 71 SGFGWTNGVVLEFI TREA_TENMO 536 63 DGFGWSNGVVLEFL TREA_BOMMO 533 63 FINAL MOTIF SETS GLHYDRLASE371 Length of motif = 19 Motif number = 1 Glycosyl hydrolase family 37 motif I - 2 PCODE ST INT YGKILNATRSYYLCRSQPP TREB_MAGGR 318 318 YGKILNANRSYYLTRSQPP TREB_EMENI 328 328 YGKILNATRSYYLCRSQPP TREB_NEUCR 325 325 YGKILNANRSYYLGRSQPP TREA_CANAL 490 490 YGKILNANRSYYLCRSQPP TREA_KLULA 344 344 YGKILNANRSYYLCRSQPP TREA_YEAST 341 341 YGKILNANRTYYLLRSQPP TREA_SCHPO 322 322 YGHIPNGGRVYYLQRSQPP TREA_RABIT 207 207 YSKILNANRSYYLCRSQPP TREB_YEAST 370 370 FGHIPNGSRWYYQERSQPP TREA_BOMMO 200 200 YGHVPNGGRVYYLQRSQPP TREA_HUMAN 207 207 FGHIPNGSRWYYQERSQPP Q27453 200 200 YGHIPNGNRSYYLSRSQPP TREA_ECOLI 191 191 YGFIPNGTRVYYLNRSQPP Q22195 179 179 YGYALNGARAYYTNRSQPP O22986 202 202 YGHIPNGNRTYYLSRSQPP TREF_ECOLI 207 207 YGFIPNGARVFYLNRSQPP TREA_TENMO 203 203 YGFVPNGGRVYYLQRSQPP Q23176 195 195 HGFVPNGGRVYYLTRSQPP O44736 184 184 GLHYDRLASE372 Length of motif = 18 Motif number = 2 Glycosyl hydrolase family 37 motif II - 2 PCODE ST INT LSRYRPEGAGVPPETEAD TREB_MAGGR 386 49 LSRYRSPGIGVPPETEAS TREB_EMENI 396 49 LSRYRPEGLGVPPETEAG TREB_NEUCR 393 49 LSCYHPEGKGIPPETEPT TREA_CANAL 563 54 LSCYHPDGIGIPPETEPG TREA_KLULA 414 51 LSRYHPNGLGIPPETESD TREA_YEAST 411 51 LSRYRPGGLGIPPETEAS TREA_SCHPO 390 49 LNRYHVPYGGPRPESYSK TREA_RABIT 275 49 LSCYHSDGIGIPPETEPD TREB_YEAST 440 51 LLRYYIPSAGPRPESYYE TREA_BOMMO 268 49 LNRYYVPYGGPRPESYSK TREA_HUMAN 275 49 LLRYYIPSAGPRPESYYE Q27453 268 49 LNRYWDDRDTPRPESWVE TREA_ECOLI 266 56 LYRFVVETSHPRPESYRE Q22195 245 47 LSRYYAMWNKPRPESSVF O22986 272 51 LNRYWDDRDTPRDESWLE TREF_ECOLI 281 55 LAQYNSNSGSPRPESYYE TREA_TENMO 271 49 VYQYKTASNVPRPESYRV Q23176 263 49 YYQYKAKLKVPRPESYRE O44736 254 51 GLHYDRLASE373 Length of motif = 18 Motif number = 3 Glycosyl hydrolase family 37 motif III - 2 PCODE ST INT FLHDRAVRESGHDTSYRL TREB_MAGGR 441 37 FMHDRAVRESGHDTSYRL TREB_EMENI 451 37 FMHDRAVRESGHDTTYRF TREB_NEUCR 448 37 FLHDRAVRESGHDTSYRL TREA_CANAL 619 38 FLHDRGVRESGHDTTYRF TREA_KLULA 469 37 FLHDRGVRESGHDTTYRF TREA_YEAST 466 37 FVHDRAVRESGHDTTYRL TREA_SCHPO 445 37 WAELKAGAESGWDFSSRW TREA_RABIT 309 16 FLHDRAVRESGHDTTYRF TREB_YEAST 495 37 YADLKSAAESGWDFSTRW TREA_BOMMO 303 17 WAELKAGAESGWDFSSRW TREA_HUMAN 309 16 YADLKSAAESGWDFSTRW Q27453 303 17 YRDLRSAAASGWDFSSRW TREA_ECOLI 300 16 WGDLAAAAESGRDFSSRF Q22195 280 17 HRDIATAAESGCDFSTRW O22986 307 17 YRDLRAGAASGWDYSSRW TREF_ECOLI 314 15 YMDLKSAAESGWDFSSRW TREA_TENMO 306 17 YQDLASAAESGWDFSTRW Q23176 298 17 WSEIASAAETGWDFSTRW O44736 289 17 GLHYDRLASE374 Length of motif = 18 Motif number = 4 Glycosyl hydrolase family 37 motif IV - 2 PCODE ST INT LATVDLNTLLFKYETDIA TREB_MAGGR 465 6 LATVDLNSLLYKYEVDIA TREB_EMENI 475 6 LATIDLNSLLFKYETDIA TREB_NEUCR 472 6 LATVDLNSLLYKYENDIA TREA_CANAL 643 6 LATIDLNSLLYKYEVDIA TREA_KLULA 493 6 LATIDLNSLLYKYEIDIA TREA_YEAST 490 6 LATVDLNSLLYKYETDIS TREA_SCHPO 469 6 LVPVDLNAFLCQAEELLS TREA_RABIT 344 17 LATIDLNSLLYKYEKDIA TREB_YEAST 519 6 VIPVDLNAIFAGALQITA TREA_BOMMO 340 19 LVPVDLNAFLCQAEELMS TREA_HUMAN 344 17 VIPVDLNAIFAGALQITA Q27453 340 19 IVPVDLNSLMFKMEKILA TREA_ECOLI 332 14 LIPVDLNSIICGNMKTLS Q22195 316 18 VVPVDLNVFLLKMELDIA O22986 339 14 FIPIDLNAFLFKLESAIA TREF_ECOLI 346 14 IIPVDLNAFLCQAFQKLS TREA_TENMO 343 19 VLPVDLNGLLCWNMDIME Q23176 330 14 IIPADLNAFMCANARILA O44736 328 21 GLHYDRLASE375 Length of motif = 17 Motif number = 5 Glycosyl hydrolase family 37 motif V - 2 PCODE ST INT IDKYLWNEEAGMYFDYD TREB_MAGGR 526 43 MDTYLWDEEKGMYFDYD TREB_EMENI 536 43 IDKYLWNEEAGMYFDYN TREB_NEUCR 534 44 VDKYLWNEQDGIYYDYN TREA_CANAL 700 39 IDKYLWDEETGFYYDYN TREA_KLULA 545 34 ITKYMWDDESGFFFDYN TREA_YEAST 543 35 MEKYLWSEADSMWYDYN TREA_SCHPO 521 34 LTALLWDEDKGAWFDYD TREA_RABIT 387 25 INKYMWDEDSGFFFYYN TREB_YEAST 572 35 IEQALWDEEDGVWHDYD TREA_BOMMO 383 25 LNTVLWDEQTGAWFDYD TREA_HUMAN 387 25 IEQALWDEEDGVWHDYD Q27453 383 25 IEKYLWNDQQGWYADYD TREA_ECOLI 375 25 IRQVLWNEEHNCWFDFD Q22195 359 25 FQTVFWNEKAGQWLDYW O22986 382 25 VNRYLWDDENGIYRDYD TREF_ECOLI 389 25 IEMVHYNRDDGIWYDWD TREA_TENMO 386 25 VQNVFYNRTDGTWYDYN Q23176 373 25 MRELHWNETDGIWYDYD O44736 371 25 GLHYDRLASE376 Length of motif = 17 Motif number = 6 Glycosyl hydrolase family 37 motif VI - 2 PCODE ST INT GLDRPNRQWDYPYGWAP TREB_MAGGR 599 56 GLNRPTRQWDYPYGWAP TREB_EMENI 609 56 GLERPNRQWDYPYGWAP TREB_NEUCR 607 56 GLTRPSRQWDYPFGWAP TREA_CANAL 773 56 SLDRPTRQWDYPFGWAP TREA_KLULA 618 56 SISRPIRQWDYPFGWAP TREA_YEAST 616 56 GLDNPSRQWDYPNGWSP TREA_SCHPO 594 56 SLQNTGQQWDFPNAWAP TREA_RABIT 454 50 SIDRPIRQWDYPFGWAP TREB_YEAST 645 56 SLVNSGEQWDFPNAWPP TREA_BOMMO 453 53 SLQKTGQQWDFPNAWAP TREA_HUMAN 454 50 SLINSGEQWDFPNAWPP Q27453 453 53 TSVKSGQQWDAPNGWAP TREA_ECOLI 439 47 SLVNSGEQWDFPNSWPP Q22195 426 50 SLTNSGQQWDSPNGWAP O22986 451 52 SEYETGEQWDKPNGWAP TREF_ECOLI 452 46 SLSHTGEQWDYPNAWPP TREA_TENMO 456 53 MSQESDQQWDFPNGWSP Q23176 443 53 LAMSSTQQWDKENAWPP O44736 440 52 GLHYDRLASE377 Length of motif = 14 Motif number = 7 Glycosyl hydrolase family 37 motif VII - 2 PCODE ST INT EGFGWVNASYIYGL TREB_MAGGR 687 71 EGFGWVNASYVYGL TREB_EMENI 697 71 EGFGWVNASYVYGL TREB_NEUCR 695 71 EGFGWVNASYVFGL TREA_CANAL 861 71 EGFGWVNSSYLLGM TREA_KLULA 706 71 EGFGWVNASYILGL TREA_YEAST 704 71 EGFGWVNASYEVGL TREA_SCHPO 682 71 EGFGWTNGVALMLL TREA_RABIT 533 62 EGFGWVNTSYLLGL TREB_YEAST 733 71 DGFGWSNGVVLEFL TREA_BOMMO 533 63 EGFGWDEGVVLMLL TREA_HUMAN 534 63 DGFGWSNGVVLEFL Q27453 533 63 DGFGWTNGVTLKML TREA_ECOLI 516 60 EGFGWTNGVILDFL Q22195 505 62 TGFGWSNGVILAFL O22986 531 63 DGFGWTNGVVRRLI TREF_ECOLI 530 61 SGFGWTNGVVLEFI TREA_TENMO 536 63 DGFGWSNGAILDLL Q23176 524 64 TGFGWTNGVILDLL O44736 523 66

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