WORKLIST ENTRIES (1):

GLHYDRLASE26 View alignment     Glycosyl hydrolase family 26 signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   PRINTS; PR00131 GLHYDRLASE1; PR00132 GLHYDRLASE2; PR00133 GLHYDRLASE3
   PRINTS; PR00732 GLHYDRLASE4; PR00733 GLHYDRLASE6; PR00734 GLHYDRLASE7
   PRINTS; PR00735 GLHYDRLASE8; PR00134 GLHYDRLASE10; PR00911 GLHYDRLASE11
   PRINTS; PR00736 GLHYDRLASE15; PR00737 GLHYDRLASE16; PR00738 GLHYDRLASE20
   PRINTS; PR00740 GLHYDRLASE27; PR00741 GLHYDRLASE29; PR00843 GLHYDRLASE30
   PRINTS; PR00742 GLHYDRLASE35; PR00743 GLHYDRLASE36; PR00744 GLHYDRLASE37
   PRINTS; PR00745 GLHYDRLASE39; PR00746 GLHYDRLASE41; PR00747 GLHYDRLASE47
   PRINTS; PR00844 GLHYDRLASE48; PR00845 GLHYDRLASE52; PR00846 GLHYDRLASE56
   PRINTS; PR00849 GLHYDRLASE58; PR00850 GLHYDRLASE59; PR00748 MELIBIASE
   PRINTS; PR00137 LYSOZYME; PR00684 T4LYSOZYME; PR00749 LYSOZYMEG
   PRINTS; PR00110 ALPHAAMYLASE; PR00750 BETAAMYLASE
   INTERPRO; IPR000805

 Creation date 10-JUN-1997; UPDATE 07-JUN-1999

   1. HENRISSAT, B. AND BAIROCH, A.
   New families in the classification of glycosyl hydrolases based on amino
   acid sequence similarities.
   BIOCHEM.J. 293 781-788 (1993).

   2. HENRISSAT, B.
   A classification of glycosyl hydrolases based on amino acid sequence
   similarities.
   BIOCHEM.J. 280 309-316 (1991).

   3. DAVIES, G. AND HENRISSAT, B.
   Structures and mechanisms of glycosyl hydrolases.
   STRUCTURE 3 853-859 (1995).

   4. HENRISSAT, B. AND BAIROCH, A.
   Updating the sequence-based classification of glycosyl hydrolases.
   BIOCHEM.J. 316 695-696 (1996).

   5. BRAITHWAITE, K.L., BLACK, G.W., HAZLEWOOD, G.P., ALI, B.R.
   AND GILBERT, H.J.
   A non-modular endo-beta-1,4-mannanase from Pseudomonas fluorescens
   subspecies cellulosa.
   BIOCHEM.J. 305(3) 1005-1010 (1995).

   O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that
   hydrolyse the glycosidic bond between two or more carbohydrates, or between
   a carbohydrate and a non-carbohydrate moiety. A classification system for
   glycosyl hydrolases, based on sequence similarity, has led to the definition
   of up to 60 different families [1-4] (http://expasy.hcuge.ch/cgi-bin/lists?
   glycosid.txt). Family 26 encompasses mainly mannan endo-1,4-beta-mannosidases.
   
   Mannan endo-1,4-beta-mannosidase hydrolyses mannan and galactomannan, but
   displays little activity towards other plant cell wall polysaccharides [5].
   The enzyme randomly hydrolyses 1,4-beta-D-linkages in mannans, galacto-
   mannans, glucomannans and galactoglucomannans.
  
   GLHYDRLASE26 is a 4-element fingerprint that provides a signature for
   family 26 glycosyl hydrolases. The fingerprint was derived from an initial
   alignment of 6 sequences: the motifs were drawn from conserved regions 
   spanning the central portion of the alignment. Two iterations on OWL29.3
   were required to reach convergence, at which point a true set comprising
   7 sequences was identified. Two partial matches were found, MANA_RHOMR and
   GUNH_CLOTM, both of which are family members that fail to make significant
   matches with one or more motifs.
  
   An update on SPTR37_9f identified a true set of 11 sequences, and 2
   partial matches.

  SUMMARY INFORMATION
     11 codes involving  4 elements
      0 codes involving  3 elements
      2 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|  11   11   11   11  
    3|   0    0    0    0  
    2|   2    0    0    2  
   --+---------------------
     |   1    2    3    4  

True positives..
 P77847         O05512         O83011         MANA_PIRSP     
 MANC_PIRSP     MANB_PIRSP     O30654         MANB_BACSU     
 MANA_RHOMR     MANB_BACSM     MANA_PSEFL     
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 O06842         Q53324         


  PROTEIN TITLES
   P77847           BETA-1,4-MANNANASE (EC 3.2.1.78) (MANNAN ENDO-1,4-BETA-MANNO
   O05512           BACILLUS SP. MANNAN ENDO-1 - BACILLUS SUBTILIS.
   O83011           BETA-MANNANASE - BACILLUS SP.
   MANA_PIRSP       MANNAN ENDO-1,4-BETA-MANNOSIDASE A PRECURSOR (EC 3.2.1.78) (
   MANC_PIRSP       MANNAN ENDO-1,4-BETA-MANNOSIDASE C PRECURSOR (EC 3.2.1.78) (
   MANB_PIRSP       MANNAN ENDO-1,4-BETA-MANNOSIDASE B PRECURSOR (EC 3.2.1.78) (
   O30654           BETA-MANNANASE (EC 3.2.1.78) (MANNAN ENDO-1,4-BETA-MANNOSIDA
   MANB_BACSU       MANNAN ENDO-1,4-BETA-MANNOSIDASE PRECURSOR (EC 3.2.1.78) (BE
   MANA_RHOMR       MANNAN ENDO-1,4-BETA-MANNOSIDASE (EC 3.2.1.78) - RHODOTHERMU
   MANB_BACSM       MANNAN ENDO-1,4-BETA-MANNOSIDASE A AND B PRECURSOR (EC 3.2.1
   MANA_PSEFL       MANNAN ENDO-1,4-BETA-MANNOSIDASE PRECURSOR (EC 3.2.1.78) (MA
 
   O06842           B14, PUTATIVE POLYGALACTURONASE, B-1,4-ENDOGLUCANASE AND MAN
   Q53324           1,4-BETA-D-ENDOGLUCANASE - PREVOTELLA RUMINICOLA (BACTEROIDE

SCAN HISTORY OWL29_3 2 100 NSINGLE SPTR37_9f 2 14 NSINGLE INITIAL MOTIF SETS GLHYDRLASE261 Length of motif = 15 Motif number = 1 Glycosyl hydrolase family 26 motif I - 1 PCODE ST INT KKYQGKGIMAAQWHW MANC_PIRSP 241 241 KKYEGKGIMAAQWHW MANA_PIRSP 242 242 KKYQGKGIMSAQWHW MANB_PIRSP 243 243 KAYARGGIITVSSHF MANA_PSEFL 130 130 SYWKSGGLPQVSLHL MANB_BACSU 116 116 NFWNQGGLVTISVHM MANB_BACSM 119 119 GLHYDRLASE262 Length of motif = 18 Motif number = 2 Glycosyl hydrolase family 26 motif II - 1 PCODE ST INT PLIWRPLHENDGDWFWWG MANC_PIRSP 309 53 PLIWRPLHENNGDWFWWG MANA_PIRSP 310 53 PLIWRPLHENDGDWFWWG MANB_PIRSP 311 53 PVIFRLYHENTGSWFWWG MANA_PSEFL 204 59 TVLFRPLHEMNGEWFWWG MANB_BACSU 183 52 TVLFRPLHEMNGEWFWWG MANB_BACSM 187 53 GLHYDRLASE263 Length of motif = 24 Motif number = 3 Glycosyl hydrolase family 26 motif III - 1 PCODE ST INT LWKILYERMVNYHGLNNLIWLWNG MANC_PIRSP 335 8 LWKILYERMVNYHGLNNLIWLWNG MANA_PIRSP 336 8 LWKILYERMVNYHGLNNLIWLWNG MANB_PIRSP 337 8 LFRYSVEYLRDVKGVRNFLYAYSP MANA_PSEFL 233 11 LYKKIYRYMTETRGLDNLLWVYSP MANB_BACSU 218 17 AWRDMYQYFTHERKLNNLIWVYSP MANB_BACSM 222 17 GLHYDRLASE264 Length of motif = 13 Motif number = 4 Glycosyl hydrolase family 26 motif IV - 1 PCODE ST INT PVDYIDIIGVDIY MANC_PIRSP 365 6 PVDYIDIIGVDIY MANA_PIRSP 366 6 PVDYIDIIGVDIY MANB_PIRSP 367 6 GDEWVDVLGFDTY MANA_PSEFL 273 16 GSSYVDITGLDAY MANB_BACSU 254 12 GANYVDIVALDSY MANB_BACSM 258 12 FINAL MOTIF SETS GLHYDRLASE261 Length of motif = 15 Motif number = 1 Glycosyl hydrolase family 26 motif I - 2 PCODE ST INT KWWKSGGIVAFCWHW P77847 667 667 SYWKNGGIPQISLHL O05512 118 118 SYWKNGGIPQISLHL O83011 118 118 KKYEGKGIMAAQWHW MANA_PIRSP 242 242 KKYQGKGIMAAQWHW MANC_PIRSP 241 241 KKYQGKGIMSAQWHW MANB_PIRSP 243 243 DWWNMGGIVQFQWHW O30654 158 158 SYWKSGGLPQVSLHL MANB_BACSU 116 116 AWAGRDGIVSLMWHW MANA_RHOMR 690 690 NFWNQGGLVTISVHM MANB_BACSM 119 119 KAYARGGIITVSSHF MANA_PSEFL 130 130 GLHYDRLASE262 Length of motif = 18 Motif number = 2 Glycosyl hydrolase family 26 motif II - 2 PCODE ST INT PVLFRPLHEASGGWFWWG P77847 743 61 PVLFRPLHEMNGEWFWWG O05512 185 52 PVLFRPLHEMNGEWFWWG O83011 185 52 PLIWRPLHENNGDWFWWG MANA_PIRSP 310 53 PLIWRPLHENDGDWFWWG MANC_PIRSP 309 53 PLIWRPLHENDGDWFWWG MANB_PIRSP 311 53 PILWRPLHEAEGRWFWWG O30654 234 61 TVLFRPLHEMNGEWFWWG MANB_BACSU 183 52 PVLWRPLHEAAGGWFWWG MANA_RHOMR 768 63 TVLFRPLHEMNGEWFWWG MANB_BACSM 187 53 PVIFRLYHENTGSWFWWG MANA_PSEFL 204 59 GLHYDRLASE263 Length of motif = 24 Motif number = 3 Glycosyl hydrolase family 26 motif III - 2 PCODE ST INT LWKLMFDRLVNYHKLNNLIWVWNG P77847 770 9 LYKKIYHYMTDTRGLDHLIWVYSP O05512 220 17 LYKKIYHYMTDTRGLDHLLWVYSP O83011 220 17 LWKILYERMVNYHGLNNLIWLWNG MANA_PIRSP 336 8 LWKILYERMVNYHGLNNLIWLWNG MANC_PIRSP 335 8 LWKILYERMVNYHGLNNLIWLWNG MANB_PIRSP 337 8 LWRLLFDRLVNYHKINNLIWVWTT O30654 261 9 LYKKIYRYMTETRGLDNLLWVYSP MANB_BACSU 218 17 LWRLLYERLVHHHGLHNLIWVYTH MANA_RHOMR 795 9 AWRDMYQYFTHERKLNNLIWVYSP MANB_BACSM 222 17 LFRYSVEYLRDVKGVRNFLYAYSP MANA_PSEFL 233 11 GLHYDRLASE264 Length of motif = 13 Motif number = 4 Glycosyl hydrolase family 26 motif IV - 2 PCODE ST INT GDNYVDIIGEDIY P77847 801 7 GASYVDIVGLDAY O05512 256 12 GASYVDIVGLDAY O83011 256 12 PVDYIDIIGVDIY MANA_PIRSP 366 6 PVDYIDIIGVDIY MANC_PIRSP 365 6 PVDYIDIIGVDIY MANB_PIRSP 367 6 GDEYVDIVGADIY O30654 296 11 GSSYVDITGLDAY MANB_BACSU 254 12 GDAYVDIVGRDVY MANA_RHOMR 828 9 GANYVDIVALDSY MANB_BACSM 258 12 GDEWVDVLGFDTY MANA_PSEFL 273 16

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